Screening for FIP1L1::PDGFRA-associated Hypereosinophilic Syndrome in the setting of Unexplained Persistent Hypereosinophilia
Clinical Decision Support Tool
This calculator is intended for healthcare professionals. Always consider the complete clinical picture and use clinical judgment.
Clinical & Biological Parameters
Select all applicable criteria
+9
Age < 66 years
+9
Male sex
+18
Splenomegaly
(Palpable and/or radiological)
+11
No gastrointestinal involvement
+9
Lymphomatoid papulosis
+15
Elevated vitamin B12
(> 1000 ng/L)
+13
Elevated tryptase
(> 11.5 µg/L)
+12
Normal IgE levels
(< 150 kUI/L)
About the FIP-Score
- Validated screening tool for FIP1L1::PDGFRA-associated HES
- Cutoff: ≥ 48 points indicates testing recommended
- Validation: Sensitivity 85.7%, Specificity 97.0%
- Using the FIP-Score reduces testing costs by approximately 10-fold
Clinical Context
- Apply in patients with unexplained persistent hypereosinophilia
- Can be used before steroid trial
- Helps prioritize molecular testing
Scientific Reference
Stammler R, Vallée A, Rohmer J, et al. Development and validation of the FIP-Score for the screening of FIP1L1::PDGFRA-associated hypereosinophilic syndrome. Journal of Allergy and Clinical Immunology: In Practice. 2025 (in press).